Photo: Fixation and loss of resistance

Fixation and loss of resistance mutations

The top plates contain genamicin, and the bottom two rifampicin. The bottom plates are colonies of Pseudomonas aeruginosa rpoB mutants +P518 (left), and S536F (right). The presence of a colony on the top but not the bottom represents the fixation of a rifamicin-sensitive invader (GFP-PA01) introduced into the rifampicin-resistant population. Note the diversity of colony morphology, suggesting divergence from the ancestral genotype has occurred in all three genetic backgrounds.

The “Journal of Reproducible Research”?

Is it time for a Journal of Reproducible Research?  Experiments that are independently conducted in different labs that find the same outcome.  This topic has been on my mind recently, and the question of reproducibility and fraud has also been in the news.  Such a journal would protect against one-off results and science fraud. Read more of this post

Abbreviate journal titles with Jabref

I use KBibTeX to manage my references database, but I used to use Jabref.  Jabref has a handy feature that can automatically abbreviate journal names to their standard (ISO) abbreviation format.  The built-in list of abbreviations is missing a lot of common biology journals, but I have updated it with many biology journals.  You can get the most recent version of my abbreviations list from my Dropbox.

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